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Tumour Research and Immunology

  • TumorforschungImmunologie.jpg
    Photo: Institut für Neuropathologie, JLU
Short Description

In Germany, 500,000 new patients are diagnosed with cancer every year. Malignant tumours are genetic diseases; the majority of the mutations responsible are acquired in the course of a lifetime. However, these mutations are not only caused by environmental influences, hereditary factors and lifestyle, but chronic inflammation also contributes to genetic instability. During transformation of normal cells into cancer cells as well as the development of therapy resistance, tumour-inducing mutations collaborate with epigenetic mechanisms. This process is influenced by the tumor microenviroment, i.e. the interplay between tumor cells and inflammatory and stromal cells and certain tumor physiological parameters such as hypoxia and altered metabolism. One important task of immune cells is to eliminate malignant transformed cells. In the Campus Profile Area “Tumour Research and Immunology”, scientists are investigating the interaction between tumour cells, inflammatory cells and tumour stromal cells in order to gain knowledge that will help them to develop new cancer therapy strategies. Another research field of the Profile Area is application-oriented and aims at improving common methods of treatment such as chemo- and radiotherapy.

Successful Joint Research
      Participating Researchers

      At Justus Liebig University Giessen

      • Prof. Dr. med. Till Acker, Institute for Neuropathology
      • Prof. Dr. Reinhard Dammann, Institute for Genetics, Department 08
      • Prof. Dr. Stefan Gattenlöhner, Prof. Dr. Andreas Bräuninger, Institute for Pathology
      • Prof. Dr. Dr. Friedrich Grimminger, Prof. Dr. Mathias Rummel, Prof. Dr. Andre Menke, Prof. Dr. Klaudia Giehl, Dr. Rajkumar Savai, Internal Medicine, Medical Clinic IV and V
      • Prof. Dr. Dieter Körholz, Prof. Dr. Christine Mauz-Körholz, Prof. Dr. Wilhelm Wößmann, Department of Paediatric Haematology and Oncology
      • Prof. Dr. Peter Klußmann, Clinic for Ear, Nose and Throat Medicine
      • Prof. Dr. Winfried Padberg, Clinic for General, Visceral-, Thoracic-, Transplant- and Children’s Surgery
      • Prof. Dr. Elke Roeb, Centre for Internal Medicine, Medical Clinic II, Gastroenterology
      • Prof. Dr. Lienhard Schmitz, Prof. Dr. Tilman Borggrefe, Institute for Biochemistry
      • Prof. Dr. Dr. h.c. Hans-Rudolf Tinneberg, Gynaecological Clinic and Obstetrics
      • Prof. Dr. Eberhard Uhl, Clinic for Neurosurgery, Neurooncology
      • Prof. Dr. Florian Wagenlehner, Clinic und Policlinic for Urology, Children’s urology and Andrology


      At Philipps-Universität Marburg

      • Prof. Dr. Detlef Bartsch, Visceral, Thoracic and Vascular Surgery
      • Prof. Dr. Stefan Bauer, Institute of Immunology
      • Prof. Dr. Uta Bauer, Institute for Molecular Biology and Tumour Research
      • Prof. Dr. Alexander Brehm, Prof. Dr. Guntram Suske, Biomedical Research Centre
      • Prof. Dr. Rita Engenhart-Cabillic, Prof. Dr. Andrea Wittig, Clinic for Radiation Therapy
      • Prof. Dr. Thomas Gress, Clinic for Gastroenterology
      • Dr. Matthias Lauth, Institute for Molecular Biology and Tumour Research
      • Prof. Dr. Michael Lohoff, Prof. Dr. Ulrich Steinhoff, Prof. Dr. Magdalena Huber, PD Dr. Alexander Visekruna, Institute for Medical Microbiology and Hospital Hygiene
      • Prof. Dr. Rolf Müller, Institute for Molecular Biology and Tumour Research
      • Prof. Dr. Andreas Neubauer, Prof. Dr.  Andreas Burchert, Prof. Dr. Elke Pogge, PD Dr. Cornelia Brendel, Clinic for Haematology, Oncology, Immunology
      • Prof. Dr. Axel Pagenstecher, Clinic for Neuropathology
      • Prof. Dr. Thorsten Stiewe, Institute for Molecular Oncology
      • Prof. Dr. Uwe Wagner, Clinic for Gynaecology

      At Technische Hochschule Mittelhessen University of Applied Sciences

      • Prof. Dr.-Ing. Peter Czermak; Faculty of Life Science Engineering
      • Prof. Dr. Frank Runkel; Faculty of Life Science Engineering
      • Prof. Dr. rer. nat. Klemens Zink; Faculty of Life Science Engineering