Microorganisms and Viruses
- Short Description
This Campus Research Focus pools the molecular, ecological and medical expertise in microbiology, virology and parasitology of the universities of Giessen and Marburg and the THM University of Applied Sciences, with the cooperation partners Max Planck Institute for Terrestrial Microbiology in Marburg, Paul Ehrlich Institute in Langen and the University Hospital of Giessen and Marburg.
In microbiology, the interdisciplinary field of research addresses the entire spectrum of microorganisms with their ecology, pathogenesis, genetics and evolution as well as the pioneering topics of synthetic microbiology and recycling processes.
In virology the focus is on the deciphering of the molecular mechanisms of common viral diseases such as influenza on the one hand and emerging diseases caused by Ebola- or MERS coronavirus on the other.
Parasitology research concentrates on malaria and schistosomiasis, as well as infection models and the development of active agents and vaccines.
All areas involved in this Campus Research Focus aim to obtain a basic mechanistic understanding of microbes and viruses from the molecular and cellular level via microbiotic communities all the way through to preclinical models. In this context, the researchers are particularly interested in identifying overarching strategies that microbes and viruses use, and seeing how they interact – with each other and with the host. The focus of the translational research here is on the prevention and treatment of infectious diseases, the utilisation of microorganisms, the improvement of technologies in the pharmaceutics industry, the agricultural sciences and the chemicals industry.
These approaches of basic and translational research lead to close cooperation with the campus research areas "Infection and Inflammation", "Insect Biotechnology and Bioresources", "Digital Medicine and E-Health" and "Lung and Heart", as well as the Research Division Bioresources of the Fraunhofer Institute for Molecular Biology and Applied Ecology (IME) in Giessen.
- Successful Joint Research
Microcosm Earth Center
Funding Period: 2023 to 2030
DFG Research Training Group GRK-2937: "Nucleotide Metabolism in Microbes (MiNu)"
Funding Period: 2023 to 2032
LOEWE-Focus: Tree-M - Mechanisms of resilience and environmental impact of the leaf microbiome of trees
Funding Period: 2023 to 2026
LOEWE-Focus: CoroPan - Human and zoonotic coronaviruses: conserved targets for new therapeutic options in future pandemics
Funding Period: 2023 to 2026
LOEWE-Focus: Diffusable Signals - Impact of Diffusable Signals At Human Cell-Microbe Interfaces
Funding Period: 2021 to 2025
DFG Collaborative Research Center SFB 1021: RNA Viruses: Metabolism of Viral RNA, Host Cell Immune Response and Viral Pathogenesis (joint project with the campus foci Hospital Hygiene and Microbiology and Virology)
Funding Period: 2013 to 2025
- DFG Collaborative Research Centre CRC 84: Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia
Funding Period: 2010 to 2023
- DFG Collaborative Research Centre CRC/Transregio 81: Chromatin Changes in Differentiation and Malignancies
Funding period: 2010 to 2022
- DFG Collaborative Research Centre CRC/Transregio 174: Spatiotemporal dynamics of bacterial cells
Funding period: 2017 to 2021
- DFG Collaborative Research Centre CRC 987: Microbial Diversity in Environmental Signal Response
Funding period: 2012 to 2024
- DFG Collaborative Research Centre CRC 1021: RNA Viruses – RNA Metabolism, Host Response and Pathogenesis
Funding period: 2013 to 2024
- DFG Collaborative Research Centre CRC 593: Mechanisms of Cellular Compartmentation and the Relevance for Disease
Funding period: 2003 to 2014
- DFG Collaborative Research Centre CRC 535: Invasion Mechanism and Replication Strategies of Infectious Agents
Funding period: 1997 to 2008
- DFG Collaborative Research Centre CRC 395: Interaction, Adaptation and Catalytic Capability of Soil Microorganisms
Funding period: 1996 to 2007
- Participation in DFG Priority Programme SPP 1935: Deciphering the mRNP code: RNA-bound determinants of post-transcriptional gene regulation
Funding Period: since 2016
- DFG Priority Programme SPP 1710: Dynamics of Thiol-Based Redox Switches in Cellular Physiology
Funding period: 2014 to 2022
- Participation in DFG Priority Programme SPP 1596: Ecology and Species Barriers in Emerging Viral Diseases; subproject "Antiviral Factors of Type 1-Interferon Systems of Small Mammals"
Funding Period: 2013 to 2020
- DFG Research Training Group RTG 2355: Regulatory networks in the mRNA life cycle: from coding to noncoding RNAs
Funding Period: 2018 to 2028
- DFG Research Training Group RTG 2213: Membrane Plasticity in Tissue Development and Remodeling
Funding period: 2016 to 2021
- DFG International Research Training Group IRTG 767: Transcriptional Control in Developmental Processes
Funding period: 2002 to 2010
- DFG Clinical Research Unit KFO 309: Virus-induced Lung Injury: Pathobiology and Novel Therapeutic Strategies
Funding period: 2016 to 2022
- LOEWE Centre: Novel Drug Targets against Poverty-Related and Neglected Tropical Infectious Diseases (DRUID)
Funding period: 2018 to 2023
- LOEWE Research Cluster: MOSLA – Molecular Long-Term Data Storage
Funding period: 2019 to 2023
- Research Infrastructure
- High Security BSL-4-Laboratory at Philipps-Universität Marburg – the only laboratory of its kind at a university in Germany
- “BiGi - The Bielefeld-Giessen Resource Center for Microbial Bioinformatics” – In cooperation with the campus research focus “Biomedical Informatics and E-health”
- DFG core facility: Marburg Core Facility for Interactions, Dynamics and Macromolecular Assembly Structure
German Research Foundation.
- Centre for Synthetic Microbiology (SYNMIKRO) – joint research institution by the Philipps-Universität Marburg and the Max Planck Institute for Terrestrial Microbiology (from 2011 to 2018 funded through LOEWE)
- Research Environment
- German Centre for Infection Research (DZIF); the Justus Liebig University, Philipps-Universitaet Marburg, Technische Hochschule Mittelhessen University of Applied Sciences and the Paul-Ehrlich-Institut Langen form the DZIF-site Gießen-Marburg-Langen; speaker Trinad Chakraborty (JLU), deputy speaker Stephan Becker (UMR)
- Paul-Ehrlich Institute, Langen – Federal Institute for Vaccines and Biomedicines
- Max Planck Institute for Heart and Lung Research, Bad Nauheim
- Participating Researchers